John Cena is enjoying a dream run as the Undisputed WWE Champion and has been retaining his championship since winning it at Wrestlemania 41. The 17-time world champion successfully defended his title against Randy Orton at Backlash. He defeated CM Punk in the main event of Night of Champions to continue his reign. Cena wants to retire with the championship and his wish could come true. As the fans wait for Cena's next title defence, here we have a look at 3 WWE superstars who can dethrone him.

Roman Reigns could be one of the top picks to dethrone John Cena as the Undisputed WWE Champion. The OTC is the biggest WWE superstar of the present era despite being a part-timer. Reigns hasn't held a title since April 2024 and a win over Cena could be the best way for him to return to the title picture.

Reigns is on a break from WWE since April. He made his previous WWE appearance on Raw after Wrestlemania 41.

Cody Rhodes is one of the favourites to dethrone Cena as the champion. The American Nightmare could very well regain the championship in the main event of SummerSlam 2025. Cody lost the title to Cena at Wrestlemania 41.

Cody earned the title opportunity against Cena after winning the King of the Ring. He retained the title for over a year before losing to Cena.

Seth Rollins holds the Money in the Bank briefcase and the only thing he needs to win the championship is to pin Cena or his opponent during a match. The fact that Rollins holds the MITB briefcase makes him one of the top contenders to win the championship.

Rollins tried to cash-in the briefcase in the main event of Night of Champions but missed out winning the title as Cena dumped him out of the ring.